4-Aminophenylboronic acid pinacol ester, commonly associated with CAS 214360-73-3, is an aryl boronic ester used mainly as a building block in palladium-catalyzed cross-coupling chemistry. It contains both an aryl boronate ester and a para-amino group, giving it two useful functional handles for synthetic development. The name “picol ester” may appear in some product descriptions, but buyers should verify the structure because CAS 214360-73-3 is commonly indexed as 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, also called 4-aminophenylboronic acid pinacol ester.
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Based on the commonly assigned structure, its molecular formula is C12H18BNO2 and its relative molecular mass is approximately 219.09 g/mol. The compound is generally supplied as a research or manufacturing intermediate rather than as a finished active ingredient. At Maison Chemical, I recommend confirming the requested name, CAS number, molecular structure, purity, packaging, and analytical documentation before placing a bulk order.
This material is an aromatic boronic ester in which a boron-containing pinacol ester group is attached to an aniline ring. The amino group is positioned para to the boronate ester, which is why the compound is often described as a 4-amino or para-amino phenylboronic ester. The boronate ester helps provide a more manageable form of an aryl boronic acid for storage and synthetic handling, although its stability still depends on moisture, temperature, packaging, and the surrounding chemical environment.
The key identification values commonly used by buyers are the CAS number 214360-73-3, the approximate molecular weight of 219.09 g/mol, and the molecular formula C12H18BNO2. The calculated boron content is approximately 4.9% by mass, based on the stated formula and atomic weights. These values are useful for initial screening, but they do not replace confirmation by a supplier certificate of analysis.
PubChem is a suitable public reference for checking chemical identity, synonyms, structure records, and calculated properties; however, a public database record does not confirm the quality of a particular production lot. I therefore treat the supplier’s lot-specific certificate of analysis, chromatographic data, and agreed specification as the controlling documents for procurement.
The principal synthetic role of this compound is as an aryl boronate partner in Suzuki–Miyaura coupling. In a typical coupling strategy, the aryl boronate reacts with an aryl or heteroaryl halide in the presence of a suitable palladium catalyst and base to form a new carbon–carbon bond. This makes the material relevant to medicinal chemistry, pharmaceutical intermediate development, agrochemical research, and advanced organic synthesis.
The para-amino group can remain available for later transformation or can be protected when the reaction sequence requires improved chemoselectivity. Depending on the route, chemists may use the amino group in acylation, sulfonylation, urea formation, reductive amination, or other nitrogen-functionalization steps. The appropriate order of coupling and amino-group protection must be established experimentally for each substrate combination.
Research teams may select this intermediate when they need to introduce a para-aminophenyl unit into a more complex molecular framework. Process-development groups may also evaluate it as a step in a multistage route, where impurity control, catalyst removal, reaction conversion, and isolation behavior become more important than simple catalog availability. A small-scale reaction result should not automatically be treated as evidence of commercial-scale performance.
Potential use areas include small-molecule discovery, linker synthesis, heterocycle development, material-functionalization research, and preparation of advanced intermediates. The exact suitability depends on the reaction partners, catalyst system, solvent, base, temperature, and downstream purification method. I recommend a route-specific technical review rather than selecting the material solely because it contains a boronate ester.
| Specification | Common reference or buyer requirement | Why it matters |
|---|---|---|
| CAS number | 214360-73-3 | Confirms the intended registered chemical identity. |
| Common chemical name | 4-Aminophenylboronic acid pinacol ester | Helps distinguish the compound from other aminophenyl boronic acids. |
| Molecular formula | C12H18BNO2 | Supports formula checks, stoichiometric calculations, and analytical review. |
| Approximate molecular weight | 219.09 g/mol | Used for molar calculations and reaction charging. |
| Calculated boron content | Approximately 4.9% by mass | Provides a theoretical elemental-composition reference. |
| Purity target | Define by project, for example 95% or 98% minimum | Higher purity may be necessary for sensitive route or impurity profiles. |
| Pack size | Confirm in grams or kilograms | Packaging affects moisture exposure, handling, and total landed cost. |
Purity should be interpreted together with the analytical method. HPLC area percentage, assay by another validated method, water content, residual solvents, palladium or other metal residues, and individual unknown impurities can affect whether a lot is acceptable. For a regulated or late-stage project, I recommend agreeing on the analytical method and release limits before commercial purchasing.
The chemical name also deserves special attention. “Picol ester” and “pinacol ester” are not interchangeable descriptions in a procurement specification unless the structure has been checked. Before issuing a purchase order, I suggest comparing the CAS number, structure image, molecular formula, molecular weight, and supplier CoA to prevent a naming mismatch.
For early-stage synthesis, buyers often need gram-level quantities for reaction screening and analytical development. For route development, the requirement may increase to hundreds of grams or kilograms, with greater emphasis on batch consistency, reproducible impurity profiles, and delivery planning. The best specification is therefore the one that reflects the intended stage of use rather than a generic catalog description.
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Boronate esters can be sensitive to moisture and prolonged exposure to unsuitable conditions, but the exact storage recommendation should come from the product-specific safety data sheet and stability information. I advise customers to request the recommended storage temperature, light protection requirements, container type, retest period, and any available stability data. Standard laboratory precautions, including appropriate personal protective equipment and controlled handling, should be followed according to the SDS.
For scale-up, the reaction process may be influenced by the amount of water, base selection, catalyst loading, order of addition, and work-up conditions. These variables can change conversion and impurity formation, so they should be evaluated during process development rather than assumed from a literature procedure. The supplier can support material selection, but the customer’s process team remains responsible for process-specific validation.
I recommend starting with identity confirmation instead of price comparison. Ask each supplier to provide the CAS number, structure, molecular formula, molecular weight, available purity grades, and a recent representative CoA. If the supplier uses “picol ester,” ask for written confirmation that the offered material is the same compound as the requested CAS 214360-73-3.
A useful document package may include a certificate of analysis, HPLC or GC data where applicable, water content, residual solvent information, SDS, packaging details, and batch or lot traceability. Not every project requires the same level of documentation, but the requirements should be defined before shipment. For pharmaceutical or other regulated development, customers should also review whether the supplier can support additional quality agreements or customer-specific documentation.
Price alone does not describe the real purchasing cost. Buyers should compare purity, net quantity, packaging, lead time, minimum order quantity, transport conditions, payment terms, documentation, and the supplier’s ability to repeat the same specification in later batches. A lower initial price may be less attractive if the material requires extensive incoming testing or causes delays in a time-sensitive synthesis program.
At Maison Chemical, I can support customers with product identity confirmation, specification alignment, quotation preparation, packaging discussions, and export-oriented order coordination. Availability, minimum order quantity, lead time, and documentation depend on the requested grade and order size, so I provide those details against the customer’s actual inquiry rather than making a general promise.
CAS 214360-73-3 identifies a chemical substance, but it does not by itself establish a universal purity, appearance, storage life, or manufacturing route. Different suppliers may offer different grades, analytical methods, and packaging configurations under the same CAS number. A buyer should therefore avoid treating an online listing as a complete technical specification.
The compound may not be the best choice for every coupling route. Some reactions may benefit from a different boronic acid, boronate ester, trifluoroborate salt, or protected aniline derivative, depending on hydrolytic stability, reaction compatibility, purification, and cost. Route selection should be based on experimental evidence, impurity control, and total process requirements.
PubChem and other chemical databases can help establish a preliminary identity, while the supplier’s CoA and SDS provide lot-specific and handling-related information. For safety, transport, and regulatory decisions, I recommend using the current documentation supplied for the exact batch and destination country.
In practical B2B terms, CAS 214360-73-3 is commonly supplied as 4-aminophenylboronic acid pinacol ester, an aryl boronate building block used to construct carbon–carbon bonds and prepare more complex organic intermediates. Its approximate molecular formula is C12H18BNO2, and its approximate molecular weight is 219.09 g/mol. The compound is particularly relevant when a synthesis requires both a boronate coupling function and a para-amino group.
The next step is to confirm whether the requested “picol ester” wording refers to this pinacol ester structure. I recommend sending the target CAS number, required purity, estimated quantity, packaging preference, destination, and documentation requirements to the supplier for review. Maison Chemical can then prepare a specification-based quotation and clarify available supply, analytical documents, MOQ, and lead time for your project.
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