2-Fluoro-4-(trifluoromethyl)phenylboronic acid, CAS 503309-11-3, is an aromatic boronic acid used primarily as a building block for carbon–carbon bond formation, especially Suzuki–Miyaura coupling. Its structure combines a boronic acid group with both fluoro and trifluoromethyl substituents, making it relevant to medicinal chemistry, pharmaceutical intermediate development, and other research programs that require a fluorinated aryl fragment. The commonly assigned molecular formula is C7H5BF4O2, with a calculated molecular weight of approximately 207.92 g/mol.
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As a buyer, I recommend confirming identity, assay, water content, residual solvents, packaging, and intended scale before placing an order. These details can affect reaction performance, storage planning, and total sourcing cost. At Maison Chemical, I support customers with product discussions, documentation coordination, packaging options, and quotations based on their technical and commercial requirements.
This guide is intended for pharmaceutical and fine-chemical companies, contract research organizations, process development teams, and academic laboratories evaluating CAS 503309-11-3. It is also useful for purchasing professionals who need to compare suppliers beyond a simple catalog price. The information is designed for sourcing and planning rather than as a substitute for a validated laboratory procedure or regulatory assessment.
Buyers may approach this material at different stages, including route scouting, medicinal chemistry library synthesis, process optimization, or pilot-scale preparation. Each stage can require a different combination of purity, quantity, analytical support, and delivery flexibility. I therefore recommend matching the specification to the actual reaction and project risk instead of selecting only by the lowest unit price.
2-Fluoro-4-(trifluoromethyl)phenylboronic acid belongs to the arylboronic acid family. The boronic acid group is commonly used as a coupling handle, while the fluoro and trifluoromethyl groups remain part of the aromatic product after a successful coupling reaction. This makes the compound useful when a project needs a fluorinated substituted phenyl moiety in a more complex target.
The structure contains one boron atom, four fluorine atoms in total, and two oxygen atoms associated with the boronic acid functionality. The approximate molecular weight is 207.92 g/mol, and the formula is generally represented as C7H5BF4O2. Buyers should still verify the formula, molecular weight, and structure against the supplier’s current specification sheet and certificate of analysis before using the data for calculations.
The main value of this compound is its arylboronic acid functionality. Under suitable reaction conditions, arylboronic acids can participate in palladium-catalyzed Suzuki–Miyaura coupling with appropriate aryl or heteroaryl halides. The exact conversion depends on the reaction partner, catalyst system, base, solvent, temperature, concentration, and work-up method, so I do not recommend assuming that one published condition will apply to every substrate.
For purchasing purposes, the key specifications are identity, assay, appearance, water content, residual solvents, and impurity profile. A typical buyer should request the current product specification and a batch-specific COA where available, rather than relying only on a general online listing. The final acceptance limits should be agreed before shipment if the material is intended for a regulated or scale-up process.
| Item | Buyer Consideration |
|---|---|
| Product | 2-Fluoro-4-(trifluoromethyl)phenylboronic acid |
| CAS number | 503309-11-3 |
| Approximate molecular formula | C7H5BF4O2 |
| Approximate molecular weight | 207.92 g/mol |
| Common use | Arylboronic acid intermediate for research and synthesis |
| Documentation to request | Specification, COA, analytical data, and safety information as applicable |
CAS number and molecular formula are useful for initial identification, but they do not by themselves confirm batch quality. I suggest reviewing chromatographic purity, NMR or other identity data, and any reported inorganic or process-related impurities. If the compound is sensitive to moisture or prolonged storage conditions in your process, ask the supplier to clarify packaging and recommended handling based on the available product data.
In practice, buyers may compare several supply formats rather than different chemical structures. These can include research quantities, larger development quantities, standard commercial packaging, or a project-specific production batch. The appropriate option depends on expected consumption, shelf-life planning, internal testing requirements, and whether the material is being used for exploratory or process work.
Small quantities are often suitable for route screening, parallel synthesis, and early biological research. At this stage, fast access and reliable documentation may be more important than a large volume discount. I recommend confirming that the pack size is sufficient for repeat experiments while avoiding unnecessary inventory of a moisture-sensitive or infrequently used intermediate.
For process development, the buyer should discuss batch size, target assay, impurity limits, packaging, and analytical method expectations before requesting a firm quotation. A scale-up order may require additional production planning and quality review. Maison Chemical can evaluate the requirement and coordinate a supply proposal according to the requested quantity, specification, and delivery destination.
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This compound is most directly matched to synthetic programs that need the 2-fluoro-4-trifluoromethylphenyl group introduced through a boronic acid coupling route. It may be considered for pharmaceutical intermediate research, medicinal chemistry analog preparation, and custom synthesis projects. The suitability of the material should be judged together with the coupling partner and the downstream purification strategy.
For early discovery work, a commercially available research-grade material may be adequate if the laboratory can confirm identity and purity before use. For route optimization or process transfer, tighter controls on assay, water, residual solvents, and impurity reproducibility may be more important. If the final application involves a regulated active ingredient or intermediate, the buyer should define documentation and quality expectations at the beginning of supplier discussions.
Begin by confirming the full chemical name, CAS 503309-11-3, molecular formula, and approximate molecular weight. Request the applicable specification and a representative or batch-specific COA, depending on the project stage. If your laboratory uses a defined analytical method, communicate the required data format before ordering.
State the required quantity, target delivery date, destination country, and whether repeat supply is expected. MOQ and lead time can vary according to stock status, batch planning, packaging, and export documentation. I recommend requesting a written quotation that separates product cost, packaging, transportation, and any other applicable charges.
Ask how the material will be packaged for the requested quantity and whether special handling instructions apply. Packaging should protect the product during normal transport and align with the customer’s storage and sampling procedures. The buyer should also review the supplier’s safety documentation and conduct its own site-specific risk assessment.
A single successful laboratory purchase does not always demonstrate long-term supply suitability. For recurring projects, discuss batch consistency, forecast visibility, change notification practices, and the possibility of repeat production. These points can reduce avoidable delays when a medicinal chemistry program moves toward larger development quantities.
The price of CAS 503309-11-3 may depend on quantity, purity target, packaging, testing requirements, production route, and current availability. A small catalog pack and a development-scale batch should not be compared solely on price per gram because their analytical and logistical requirements may differ. For an accurate quote, I need the required quantity, specification, destination, and expected purchasing schedule.
MOQ is not necessarily fixed across all projects. It may be possible to discuss a smaller research quantity for evaluation, while a custom batch may require a higher minimum because of production and quality-control costs. Lead time should be confirmed in writing, especially when the material is not immediately available or when additional analytical documentation is requested.
Maison Chemical approaches this product as a technical sourcing project rather than a simple item transaction. I can help review your required specification, quantity range, documentation needs, packaging expectations, and delivery schedule before a quotation is prepared. Where a requirement is not yet defined, I recommend starting with a specification discussion so that the supply proposal remains practical and verifiable.
2-Fluoro-4-(trifluoromethyl)phenylboronic acid, CAS 503309-11-3, is a fluorinated arylboronic acid used mainly as a synthetic intermediate and coupling building block. Its commonly assigned formula is C7H5BF4O2, with an approximate molecular weight of 207.92 g/mol. The best purchase decision depends on verified identity, batch quality, documentation, quantity, packaging, and delivery requirements.
Before ordering, prepare your target assay, required quantity, application stage, documentation list, and delivery date. Send these details to Maison Chemical for a product review and project-specific quotation. This approach helps align the material with your laboratory or manufacturing needs while keeping MOQ, lead time, and sourcing risk visible from the beginning.
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