2-Fluoro-6-methoxyphenylboronic acid is an organoboronic acid building block identified by CAS No. 78495-63-3. I describe it as a substituted aryl boronic acid containing a fluorine atom, a methoxy group, and a boronic acid group on the same benzene ring. Its primary value is as a coupling partner in synthetic chemistry, especially in palladium-catalyzed Suzuki–Miyaura reactions used to form aryl–aryl or aryl–heteroaryl carbon–carbon bonds.
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The compound is generally considered a research and process-development intermediate rather than a finished active ingredient. Based on its structural composition, its commonly listed molecular formula is C7H8BFO3, with a calculated molecular weight of approximately 169.95 g/mol. Actual appearance, assay, water content, residual solvents, and storage requirements should be confirmed from the current supplier specification and certificate of analysis for the specific lot.
This molecule combines three chemically important features: an aryl boronic acid group, an aromatic fluorine substituent, and an aromatic methoxy substituent. The boronic acid group is the principal reactive handle for cross-coupling, while the fluorine and methoxy groups remain available to influence the electronic and steric properties of the resulting product. Because the substituents are positioned at the 2- and 6-positions relative to the boronic acid-bearing carbon, steric effects may be relevant during reaction development.
As an aryl boronic acid, it can participate in transmetalation under suitable Suzuki–Miyaura conditions. The reaction system normally requires a compatible aryl or vinyl halide, a palladium catalyst or catalyst precursor, and a base. The exact catalyst, solvent, temperature, reaction time, and work-up should be established experimentally because performance can vary with the coupling partner and scale.
| Item | Information |
|---|---|
| Common name | 2-Fluoro-6-methoxyphenylboronic acid |
| CAS number | 78495-63-3 |
| Functional class | Substituted aryl boronic acid |
| Commonly listed molecular formula | C7H8BFO3 |
| Calculated molecular weight | Approximately 169.95 g/mol |
The most important use is as a boronic acid partner for constructing substituted biaryl and aryl–heteroaryl compounds. In a typical route, the boronic acid reacts with an aryl, heteroaryl, or vinyl halide to introduce the fluoromethoxy-substituted aromatic fragment into a larger molecule. This approach is widely used in medicinal chemistry, agrochemical research, and the preparation of advanced organic intermediates.
The fluorine atom may be retained in the final structure to modify lipophilicity, metabolic behavior, or electronic characteristics, depending on the target molecule. The methoxy group can also influence aromatic electronics and may serve as a deliberate substituent in structure–activity relationship studies. These effects are molecule-dependent, so I recommend treating them as design considerations rather than guaranteed performance outcomes.
Researchers may use this compound when screening alternative building blocks for a synthetic route or when preparing a small library of fluorinated aromatic compounds. It may also be evaluated during route scouting, impurity-reference preparation, and process optimization. Its suitability depends on the required scale, reaction conditions, impurity profile, and downstream purification strategy.
For larger-scale work, the compound should be assessed not only by nominal identity but also by its behavior during charging, dissolution, reaction, filtration, and isolation. Boronic acids can show different stability and handling characteristics depending on moisture exposure, formulation, and storage conditions. A laboratory result at millimole scale should therefore be confirmed before committing to a larger purchase or production campaign.
Buyers should first confirm that the required material is the free boronic acid and not a related ester, protected derivative, or different positional isomer. Boronate esters may offer different handling or stability characteristics, but they are not automatically interchangeable in every procedure. The exact CAS number, structure, molecular weight, and analytical data should be checked against the project’s approved chemical record.
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Some suppliers may offer the material as a standard research-grade product, while others may discuss a custom or larger-scale supply arrangement. I recommend comparing the stated assay method, impurity limits, water content, residual solvent limits, and packaging configuration rather than relying only on a product name. If the material is intended for regulated development, quality documentation must be matched to the customer’s internal requirements.
A practical specification is one that supports the intended reaction and downstream use. For example, a buyer developing a sensitive coupling reaction may need more information about trace metals, water, or closely related organic impurities than a buyer performing an early discovery screen. The appropriate acceptance criteria should be agreed before order confirmation.
Start by confirming the exact structure and reaction role. The key question is whether the project needs a 2-fluoro-6-methoxy-substituted aryl boronic acid, because positional isomers can have different reactivity and produce different final compounds. Review the proposed coupling partner, catalyst system, base, solvent, and purification method before selecting a commercial source.
Next, compare the supplier’s documentation with the project’s quality level. For exploratory research, a standard certificate of analysis may be sufficient, subject to internal approval. For process development or regulated work, the buyer may need lot-specific analytical data, traceability, change-control communication, safety information, and a defined process for handling deviations.
Price should be evaluated together with pack size, minimum order quantity, lead time, shelf-life information, shipping conditions, and replenishment options. A low unit price may not be advantageous if the requested pack size creates unnecessary inventory or if documentation is incomplete. Conversely, a higher initial cost may be reasonable when it reduces qualification work or supports a time-sensitive development program.
| Buyer question | Why it matters |
|---|---|
| Is the CAS number and positional isomer confirmed? | Prevents substitution with a chemically different building block. |
| What assay and impurity data are available? | Helps assess reaction reliability and purification requirements. |
| What quantity and delivery schedule are realistic? | Supports experiment planning and avoids unnecessary delays. |
| Can the supplier support repeat batches? | Important for scale-up, method transfer, and ongoing sourcing. |
At Maison Chemical, I support customers evaluating organic boronic acids for research, route development, and industrial sourcing. Our role is to clarify the requested identity, quantity, specification level, packaging, and delivery expectations before proposing a supply route. Availability and commercial terms can vary by batch and destination, so I recommend confirming current details directly with our team.
For a useful quotation, please provide the CAS number, desired quantity, target delivery location, intended application, and any required quality documents. If you have a customer specification, approved vendor format, or analytical requirement, sharing it at the inquiry stage helps us evaluate the request more accurately. We can also discuss whether a standard product specification or a more customized supply arrangement is appropriate for your project.
In direct answer, 2-Fluoro-6-methoxyphenylboronic acid is a specialized fluorinated and methoxylated aryl boronic acid used mainly to introduce this aromatic fragment into larger molecules through cross-coupling. It may be suitable for medicinal chemistry, agrochemical research, advanced-intermediate synthesis, and process-development projects, provided that the exact structure and lot quality meet the intended reaction requirements.
As a next step, confirm the CAS number, required quantity, purity target, analytical documentation, packaging, and delivery date. Then compare the supplier’s specification with your reaction and quality needs before placing an order. Contact Maison Chemical with your project details to request current supplier information, a quotation, and a practical sourcing assessment for CAS 78495-63-3.
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