4-Pyrazoleboronic acid pinacol ester, CAS 269410-08-4, is a boronic ester building block used primarily in synthetic and medicinal chemistry. I identify this material by its pyrazole ring and pinacol-protected boronate group, which can participate in palladium-catalyzed cross-coupling reactions after suitable reaction setup. For procurement, I recommend evaluating not only the chemical name and CAS number, but also identity testing, assay, water content, appearance, packaging, documentation, and supply continuity.
At Maison Chemical, I support buyers by organizing product specifications around their actual project requirements. The commonly referenced molecular formula is C11H17BN2O2, with a calculated molecular weight of approximately 220.08 g/mol. Because commercial specifications can vary by manufacturing route, grade, and quality agreement, I recommend confirming the current certificate of analysis before placing a production order.
This guide is intended for pharmaceutical research teams, process development groups, chemical distributors, contract research organizations, and purchasing departments sourcing 4-Pyrazoleboronic acid pinacol ester. It is especially useful when a buyer needs to compare multiple suppliers or convert a laboratory requirement into a documented purchasing specification. I also recommend using this guide when the material will be transferred from small-scale discovery work into route development or commercial supply evaluation.
The guide focuses on supplier assessment rather than experimental instructions. It explains what the product is, which specifications deserve attention, how to match grade and packaging to an application, and which questions can reduce sourcing risk. It does not replace a project-specific safety assessment, process validation, or regulatory review.
4-Pyrazoleboronic acid pinacol ester is a protected boronic acid derivative containing a pyrazole heterocycle. The pinacol ester form is commonly selected because protected boronates are convenient intermediates for assembling substituted aromatic and heteroaromatic structures. In a typical synthetic route, the boronate functionality may be used as a coupling handle, while the pyrazole ring contributes a nitrogen-containing heteroaromatic scaffold.
The CAS number 269410-08-4 is the primary identifier provided in the purchasing inquiry. I advise buyers to verify that the supplier’s label, specification sheet, quotation, and certificate of analysis all show the same CAS number and product identity. A matching CAS number is important, but it should be supported by analytical evidence rather than used as the only release criterion.
| Item | Reference information | Buyer note |
|---|---|---|
| Product name | 4-Pyrazoleboronic acid pinacol ester | Confirm the supplier’s exact naming convention |
| CAS number | 269410-08-4 | Check consistency across all documents |
| Molecular formula | C11H17BN2O2 | Use as an identity cross-check |
| Calculated molecular weight | Approximately 220.08 g/mol | Confirm against the supplier’s current specification |
| Functional group | Pinacol-protected boronate | Assess compatibility with the intended synthesis |
I recommend separating specifications into identity, purity, physical condition, and documentation. Identity may be assessed through techniques such as proton NMR, carbon NMR, mass spectrometry, and chromatographic comparison, depending on the supplier’s quality system and the buyer’s requirements. Purity is often expressed by HPLC or another agreed method, but the analytical method, reporting basis, and impurity limits should be stated clearly.
Physical specifications can include appearance, color, form, water content, residual solvents, and storage conditions. These characteristics may affect handling and reaction reproducibility, particularly when a project is sensitive to moisture or trace impurities. A buyer should avoid accepting a vague description such as “high purity” without a numerical target or a defined release method.
For a research purchase, a buyer may only require identity confirmation, a defined purity specification, and a standard certificate of analysis. For process development, I usually recommend adding tighter controls for moisture, residual solvents, trace metals, and batch-to-batch consistency when those attributes can influence the reaction. The correct specification should be proportionate to the intended use rather than unnecessarily restrictive.
Discovery chemists often value availability, reliable identity, and practical pack sizes because compounds may be screened across several reaction conditions. For this use, a clear product description and a consistent analytical package can be more useful than an overly complex specification. I recommend confirming whether the offered grade is suitable for research synthesis and whether the supplier can repeat the same quality profile in future orders.
Process teams generally need more than a catalog listing. They may require impurity profiles, residual solvent information, elemental impurity considerations, packaging controls, and a defined change-notification approach. When moving toward larger quantities, I advise buyers to request a representative sample or recent batch data before approving the supplier for a broader procurement plan.
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Distributors should evaluate label accuracy, shelf-life or retest information, packaging integrity, and document consistency. They should also confirm whether the supplier can support multiple pack sizes without changing the stated specification. If the material is intended for resale into regulated or highly controlled markets, the distributor should separately review the customer’s documentation and import requirements.
I use a four-part framework when reviewing offers for CAS 269410-08-4: product identity, quality evidence, commercial fit, and communication quality. First, the supplier should clearly identify the material and provide a specification that can be compared with competing offers. Second, the supplier should explain which tests are performed routinely and which documents are available for the actual batch.
Third, the quotation should be evaluated against the complete commercial requirement, including quantity, packaging, lead time, shipping conditions, and payment terms. A lower unit price may not represent better value if the supplier cannot provide the required documents or maintain continuity. Fourth, responsive technical communication is important because unresolved specification questions can delay release and internal approval.
| Evaluation area | Questions to ask |
|---|---|
| Identity | Does the CAS number, name, formula, and analytical evidence agree? |
| Quality | Are purity, impurities, water, and residual solvent requirements defined? |
| Supply | Can the supplier support the requested quantity and repeat orders? |
| Documentation | Are the COA, SDS, packing information, and shipping documents available? |
| Service | Can technical questions and specification changes be handled promptly? |
Pricing for 4-Pyrazoleboronic acid pinacol ester can depend on order quantity, available inventory, production planning, packaging, analytical requirements, and destination. I do not recommend publishing one universal price because a small research pack and a multi-kilogram project can involve different manufacturing and quality-control costs. Buyers should request a quotation based on quantity, required grade, delivery location, and documentation package.
Minimum order quantity is also supplier- and production-dependent. A stock quantity may be available for a smaller order, while larger or customized requirements may need a scheduled batch. Lead time should therefore be confirmed in writing, with a distinction between time for sample preparation, quality release, and final shipment.
Typical procurement documents may include a certificate of analysis, safety data sheet, product specification, packing list, and commercial invoice. Additional documents should be requested only when relevant to the buyer’s quality system or destination market. I recommend asking whether the COA is batch-specific and whether the reported test methods match the purchasing specification.
Before selecting a supplier, I suggest checking whether the company can answer technical questions without relying only on a generic catalog entry. The supplier should be able to state the available quantity, expected lead time, packaging format, storage guidance, and document availability. It is also useful to ask how the company handles out-of-specification material, batch changes, and repeat-order consistency.
Maison Chemical can support this evaluation process for buyers sourcing pharmaceutical intermediates and research-use building blocks. I can help organize product identity information, discuss specification requirements, coordinate quotations, and clarify the documentation available for the requested batch and quantity. Final acceptance should remain based on the buyer’s own quality procedures and intended application.
4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 is a protected boronate intermediate used to support the synthesis of pyrazole-containing compounds. The key procurement priorities are correct identity, defined purity testing, suitable moisture and impurity controls, reliable documentation, and a supply plan that matches the project scale. The reference formula is C11H17BN2O2, and the calculated molecular weight is approximately 220.08 g/mol, subject to confirmation against the supplier’s current product specification.
As the next step, send Maison Chemical your required quantity, target specification, packaging preference, destination, and desired delivery schedule. I can then prepare a project-specific quotation and confirm the available documentation, MOQ, lead time, and batch information. This approach gives buyers a clearer basis for comparing suppliers and selecting a practical source for CAS 269410-08-4.
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