4-Trifluoromethoxyphenylboronic acid, also known as 4-(trifluoromethoxy)phenylboronic acid, is an aromatic boronic acid used primarily as a building block in organic synthesis. Its CAS number is 139301-27-2, and its molecular formula is commonly represented as C7H6BF3O3, with a calculated molecular weight of approximately 205.93 g/mol. The molecule combines a boronic acid group with a para-trifluoromethoxy substituent, making it relevant to palladium-catalyzed cross-coupling and medicinal chemistry research.
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At Maison Chemical, I position this material as a specialty intermediate that should be evaluated through identity, assay, impurity profile, packaging, and application requirements rather than by CAS number alone. Buyers should confirm the requested grade, analytical documentation, storage conditions, and delivery format before placing a commercial order.
4-Trifluoromethoxyphenylboronic acid contains one aromatic ring, one boronic acid group, and one trifluoromethoxy group in the para position. The boronic acid functionality is the principal reactive site used in Suzuki–Miyaura coupling, where it can participate in carbon–carbon bond formation with a suitable aryl or vinyl halide under an appropriate catalytic system. The trifluoromethoxy group contributes a strongly fluorinated ether substituent that can influence electronic properties, lipophilicity, and the behavior of resulting target molecules.
Its calculated molecular weight of approximately 205.93 g/mol is useful for reaction planning, material balance calculations, and analytical method development. The exact performance of the compound in a reaction depends on the coupling partner, catalyst, base, solvent, temperature, water content, and reaction work-up. For this reason, I recommend treating the compound as a valuable synthetic input rather than assuming that the same conditions will apply across every project.
Commercial samples are generally supplied as a solid, although color and physical form can vary with purity, particle size, residual solvent, and storage history. A product description should therefore state the appearance requirement without presenting an unverified color or physical specification as a guaranteed result. Buyers should review the certificate of analysis for the actual batch being offered.
Boronic acids may be sensitive to moisture and can undergo changes during prolonged exposure to unsuitable environmental conditions. I recommend keeping the container tightly closed, minimizing repeated opening, and storing the material according to the supplier’s label and technical documentation. Before use, the laboratory should assess whether drying, sieving, or a defined dissolution procedure is appropriate for its process.
| Specification item | Why it matters | Recommended buyer action |
|---|---|---|
| Identity | Confirms that the supplied material corresponds to CAS 139301-27-2 | Request an appropriate analytical identity result, such as NMR, IR, or LC-MS data |
| Assay and related impurities | Impurities may affect coupling yield, selectivity, and downstream purification | Define the minimum assay and the most relevant impurity limits before quotation |
| Water and residual solvents | Moisture and solvent residues can influence reaction reproducibility | Request Karl Fischer or suitable residual-solvent information when required |
| Packaging and storage | Packaging affects handling, contamination risk, and shelf-life management | Confirm container type, net weight, labeling, and recommended storage conditions |
The most established application is its use as an aryl boronic acid coupling partner. In Suzuki–Miyaura chemistry, it may be combined with aryl, heteroaryl, or vinyl halides to prepare biaryl and related structures, subject to reaction-specific compatibility. These products can serve as intermediates in medicinal chemistry, agrochemical research, materials development, and other discovery programs.
The trifluoromethoxy substituent is often selected when a project requires a fluorinated aromatic fragment with distinct electronic and physicochemical characteristics. However, the presence of this group does not by itself guarantee a particular biological effect or final-product performance. The value of the intermediate must be judged in the context of the complete target structure, route design, and experimental data.
For initial laboratory screening, a team may choose a small reaction scale such as 0.05–0.20 mmol, depending on available starting materials and analytical capacity. This is a planning range rather than a universal operating instruction, and the final protocol should be established by the responsible chemist. Scale-up should be supported by a documented process that covers mixing, heat transfer, impurity control, isolation, and waste handling.
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The appropriate material option depends on the purpose of the purchase. Research teams may prioritize small quantities and rapid availability, while process-development groups usually require tighter impurity control, consistent batch documentation, and a supply plan that can support repeated orders.
A buyer may request a standard research grade, a higher-assay development grade, or a customized specification for a specific route. A commonly requested commercial threshold may be 98% assay or higher, but this should be treated as a buyer-defined requirement rather than a claim about every available batch. If the material is intended for regulated or highly controlled work, the specification should also address trace metals, residual solvents, water, analytical methods, and change-control expectations.
Supplier selection should begin with a clear product specification. I recommend confirming the CAS number, molecular formula, molecular weight, required assay, impurity limits, quantity, packaging, delivery destination, and intended application before comparing quotations. This approach helps prevent a low initial price from masking additional costs associated with re-testing, repacking, delays, or unsuitable quality.
Price should be evaluated together with assay, batch consistency, documentation, logistics, and technical responsiveness. A supplier that can explain its quality controls and communicate realistic lead times may provide lower overall sourcing risk than a supplier offering only the lowest unit price. Buyers should also distinguish between a laboratory sample quotation and a repeatable commercial supply arrangement.
At Maison Chemical, I support B2B buyers by organizing product information around the actual requirements of their synthesis and procurement teams. Depending on the project, this may include specification review, document coordination, packaging discussion, sample planning, and communication about quantity and delivery expectations. I do not treat a generic product page as a substitute for a project-specific quality discussion.
For a quotation, please provide the required quantity, target assay, preferred packaging, destination country, and any documentation requirements. If your team has a defined impurity profile or an application-specific acceptance criterion, sharing it early allows us to assess the supply request more accurately. Availability, lead time, and commercial terms should be confirmed for each order because they can vary by quantity and production schedule.
4-Trifluoromethoxyphenylboronic acid CAS 139301-27-2 is a fluorinated aromatic boronic acid used mainly as a synthetic building block for cross-coupling and related research applications. Its key reference data include the CAS number 139301-27-2, formula C7H6BF3O3, and calculated molecular weight of approximately 205.93 g/mol. The most important purchasing considerations are verified identity, assay, impurity control, moisture and residual-solvent information, packaging, and dependable supply communication.
The next step is to convert your reaction or procurement need into a written specification and request batch-level documentation before approval. Contact Maison Chemical with your quantity, quality target, packaging preference, and destination so I can help evaluate a suitable supply option for your project.
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