If you are sourcing 4-tert-Buthoxyphenyl boronic acid CAS 176672-49-4 for a Suzuki coupling project, I recommend evaluating more than price alone. You should confirm the chemical identity, analytical specification, packaging, documentation, scale availability, and supplier communication before placing an order. At Maison Chemical, we support buyers who need this aryl boronic acid for research, process development, and custom synthesis workflows by helping them match the material specification to the intended coupling route.
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This compound is generally selected as an aryl boronic acid partner for palladium-catalyzed Suzuki–Miyaura cross-coupling with suitable aryl or heteroaryl halides. The reaction outcome depends on the halide substrate, catalyst system, base, solvent, temperature, concentration, and handling of the boronic acid. I therefore treat supplier selection as a technical purchasing decision rather than a simple catalog comparison.
4-tert-Buthoxyphenyl boronic acid CAS 176672-49-4 is an aromatic boronic acid containing a phenylboronic acid functional group and a tert-butoxy substituent in the para position. The boronic acid group is the key reactive site used in Suzuki coupling, where it can participate in carbon–carbon bond formation with an appropriate aryl, vinyl, or heteroaryl halide under suitable reaction conditions.
The name may appear in purchasing systems with different spelling conventions, including “4-tert-Butoxyphenyl boronic acid.” I recommend placing the CAS number, chemical name, and intended application on every request for quotation to reduce the risk of receiving a positional isomer or a similarly named boronic acid. A commonly reported molecular formula for this structure is C10H15BO3, with a molecular weight of approximately 194.04 g/mol; buyers should still confirm the specification against the supplier’s current technical documents.
In a Suzuki coupling, this compound is used as the organoboron component, while the second coupling partner is commonly an aryl or heteroaryl chloride, bromide, iodide, or related activated substrate. The boronic acid is not a universal solution for every substrate, so the reaction must be assessed together with catalyst compatibility, base selection, solvent, temperature, and substrate stability.
For early screening, a chemist may compare several reaction concentrations, such as 0.05 M and 0.10 M, to understand solubility, mixing, and conversion behavior. These values are examples for experimental planning rather than a guaranteed operating recommendation. The appropriate concentration and reagent loading should be established from the specific substrate and validated analytical results.
Before purchasing, I suggest asking for a lot-specific certificate of analysis rather than relying only on a general product page. Useful parameters may include assay or purity, appearance, identification, water content, residual solvents, and the analytical method used for each result. If your project is moving toward process development, also request information about impurity profiles, retest or shelf-life policy, packaging materials, and storage recommendations.
| Evaluation item | What I recommend confirming |
|---|---|
| Identity | Chemical name, CAS 176672-49-4, structure, and identification method |
| Purity | Assay specification expressed as a percentage and the associated test method |
| Physical condition | Appearance, color, form, and any handling notes supplied for the lot |
| Packaging | Container type, net weight, tamper protection, and labeling details |
| Commercial support | Available quantity, production schedule, documentation, and export requirements |
For a discovery project, a standard research-grade specification may be sufficient if the material performs consistently in your screening system. For a route-development project, I would place greater emphasis on lot-to-lot consistency, traceable analytical data, and the supplier’s ability to repeat the same specification. No supplier document replaces your own incoming inspection and reaction validation.
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The right supplier depends on whether you need a small quantity for feasibility work or a dependable supply plan for repeated synthesis. A laboratory buyer may prioritize sample availability and fast technical clarification, while a process team may prioritize scale capability, change notification, packaging control, and reliable export coordination. I recommend explaining your expected quantity, target delivery window, and documentation requirements at the quotation stage.
When comparing quotations, separate the material price from the total sourcing cost. Freight, dangerous-goods classification where applicable, customs documentation, repacking, testing, and the risk of delayed delivery can all affect the final project cost. A lower unit price is not necessarily the better option if the supplier cannot provide the required lot documents or repeat supply.
One common mistake is ordering by a shortened name without stating the CAS number or substitution position. Another is accepting a purity value without checking whether it refers to area percentage, assay by another method, or a specification with undisclosed exclusions. I also advise buyers not to assume that a material suitable for a small-scale screening reaction will automatically meet process requirements.
Handling and storage should follow the supplier’s current safety data sheet and product documentation. Boronic acids can be sensitive to moisture, heat, and prolonged storage conditions depending on their structure and formulation, so the receiving laboratory should establish appropriate container control and retesting practices. If the compound will be used in a regulated or tightly controlled workflow, request the required documentation before shipment rather than after receipt.
At Maison Chemical, I focus on making the purchasing conversation technically useful and commercially clear. For 4-tert-Buthoxyphenyl boronic acid CAS 176672-49-4, I can help organize product identity confirmation, specification review, quantity planning, packaging discussion, and export quotation requirements. The exact availability, purity, lead time, and pricing should be confirmed for each inquiry because they depend on the requested quantity, lot status, and destination.
Our support is intended to help procurement teams, research chemists, and process-development groups reduce avoidable sourcing uncertainty. We do not replace your internal analytical qualification or reaction validation, but we can provide the information needed for a more structured supplier comparison. For repeat projects, you can also discuss forecast quantities and documentation expectations early so that future orders are easier to plan.
Start by sending Maison Chemical the product name, CAS 176672-49-4, required quantity, destination country, intended use, and target delivery date. If you already have an internal specification, include the required assay, impurity, packaging, and documentation standards so the quotation can be evaluated accurately. For a Suzuki coupling project, sharing whether the need is discovery screening, route development, or scale-up will also help us respond more appropriately.
In conclusion, the best way to source 4-tert-Buthoxyphenyl boronic acid is to combine chemical identity verification with lot-specific documentation, realistic quantity planning, and supplier capability assessment. Use the CAS number and structure to prevent identity errors, compare quotations on total supply risk, and validate the received lot in your own system. Contact Maison Chemical with your technical and commercial requirements for a focused quotation and supplier discussion.
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