4-Pyrazoleboronic acid pinacol ester, also described as 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, is a boronic ester building block used to introduce a pyrazolyl group through palladium-catalyzed Suzuki–Miyaura coupling. Its CAS number is 269410-08-4, and its commonly reported molecular formula is C9H15BN2O2, with a molecular weight of approximately 194.04 g/mol. For B2B procurement, I recommend confirming identity, assay, water content, residual solvents, packaging, storage conditions, and batch-specific documentation before placing a production order.
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I prepared this guide for pharmaceutical and agrochemical research teams, medicinal chemistry laboratories, contract development and manufacturing organizations, and chemical distributors evaluating this compound. It is also relevant to purchasing managers who need to compare suppliers beyond a simple catalog listing. The focus is on product identification, Suzuki coupling use, handling, supply evaluation, and practical purchasing decisions.
This material may be considered for discovery chemistry, route scouting, process development, and custom synthesis programs. The appropriate grade and quantity depend on the intended reaction, the development stage, and the documentation required by the buyer. A research-use purchase and a regulated manufacturing supply should not be evaluated using exactly the same criteria.
4-Pyrazoleboronic acid pinacol ester is a heteroaryl boronic ester. The pinacol ester protects the boronic acid functionality in a form that is commonly handled and measured in synthetic chemistry, while the pyrazole ring provides a nitrogen-containing heteroaryl fragment for molecular construction.
The compound is generally identified by CAS 269410-08-4, chemical name, molecular structure, molecular formula, and analytical data. I advise buyers to compare all of these identifiers because similar pyrazole boronic acid derivatives can have different substitution positions, salt forms, or physical properties. A CAS number alone should not replace review of the supplier’s certificate of analysis.
| Item | Information | Procurement Relevance |
|---|---|---|
| Product | 4-Pyrazoleboronic acid pinacol ester | Confirm the intended pyrazole substitution pattern |
| CAS number | 269410-08-4 | Use for identity screening and purchasing records |
| Formula | C9H15BN2O2 | Check consistency with supplier documentation |
| Approximate molecular weight | 194.04 g/mol | Useful for reaction calculations and inventory planning |
Reported appearance can vary according to particle size, crystallization, and packaging conditions, so I do not recommend approving a batch based only on color or physical appearance. Buyers should request suitable analytical evidence, such as nuclear magnetic resonance data, high-performance liquid chromatography or gas chromatography information where applicable, and water or residual solvent results when relevant to the process.
In a Suzuki–Miyaura reaction, the boronic ester can provide the pyrazolyl partner for coupling with an appropriate aryl or heteroaryl halide, pseudohalide, or related electrophile. The reaction normally requires a palladium catalyst or palladium-containing catalytic system, a base, and a compatible solvent or solvent mixture. The exact outcome depends on the electrophile, catalyst, ligand, base, temperature, concentration, and work-up conditions.
The practical value of this building block is its ability to connect a pyrazole-containing fragment with another carbon framework under cross-coupling conditions. This can support the preparation of intermediate structures for medicinal chemistry and other research programs. However, I recommend treating every reaction as substrate-specific because heteroaryl coupling can be sensitive to catalyst selection, protodeboronation, steric effects, and functional-group compatibility.
When planning a Suzuki coupling, I suggest calculating the required amount from the molecular weight of approximately 194.04 g/mol and then adding a reasonable development allowance based on the planned number of experiments. The final stoichiometry should be determined by the chemist responsible for the route, not by a generic catalog recommendation. Reaction optimization data should be generated internally for the specific substrate pair.
The most important specification is the confirmed identity of CAS 269410-08-4. After identity, buyers commonly review assay or purity, related substances, water content, residual solvents, inorganic residues, and analytical method suitability. The acceptance limits should reflect the intended application rather than relying on an undocumented “high purity” description.
For a research-grade purchase, a clear product specification and batch COA may be sufficient for initial evaluation. For process or manufacturing use, I recommend requesting additional information about manufacturing controls, packaging configuration, retest or review dates, storage recommendations, and the supplier’s approach to change notification. These requirements should be agreed before the order is confirmed.
Boronic esters should be protected from unsuitable moisture, heat, and contamination during storage and handling. The exact storage condition should follow the supplier’s approved label and COA, because stability can depend on packaging, residual moisture, and the product’s physical form. I recommend keeping the container tightly closed and minimizing unnecessary exposure during sampling.
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Laboratory personnel should consult the current safety data sheet before use and apply the customer’s established controls for weighing, dust management, personal protection, and waste disposal. A supplier should not be expected to replace the buyer’s site-specific risk assessment. If the material is being shipped internationally, the buyer should also confirm the required transport and customs documentation before dispatch.
First, I recommend stating whether the material is for analytical research, medicinal chemistry, route development, scale-up, or manufacturing. This determines the appropriate documentation, quantity, packaging, and quality expectations. It also helps suppliers provide a quotation that is technically and commercially relevant.
Next, compare the requested CAS number, chemical name, molecular formula, molecular weight, purity target, packaging, and testing requirements. If your process is sensitive to water or a specific impurity, include that requirement in the inquiry rather than asking for a general quotation. Buyers should request a representative COA or an agreed specification before approving a new source.
Supplier assessment should cover available stock, production capacity, lead time, minimum order quantity, packaging options, export experience, and communication quality. Maison Chemical supports B2B inquiries for 4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 by discussing product requirements, documentation, quantity, and delivery expectations before quotation. We provide a practical contact point for buyers who need to align technical and commercial details.
Pricing can vary with quantity, purity requirements, packaging, testing, destination, and whether the material is supplied from stock or scheduled for production. Lead time should therefore be confirmed for the specific requested quantity instead of inferred from a small-pack listing. For planning purposes, buyers should communicate their target quantity in kilograms or grams, desired delivery date, destination country, and any import documentation requirements.
One common mistake is comparing suppliers only by price per gram while ignoring purity definition, analytical documentation, packaging, and delivery terms. A lower initial price may not provide the quality evidence needed for a development or manufacturing decision. I recommend comparing the complete delivered specification and commercial offer.
Another mistake is assuming that all pyrazole boronic esters behave identically in coupling reactions. Position isomers and chemically different derivatives can produce different reactivity and analytical profiles. Buyers should check the structure, CAS number, and sample data against the route requirement before ordering.
A further risk is delaying documentation requests until after production has started. If your organization needs a COA, SDS, origin statement, residual solvent information, or a specific package size, make that clear at the inquiry stage. Early clarification reduces avoidable delays in purchasing, quality review, and customs clearance.
Maison Chemical approaches this product as a B2B chemical supply project rather than a simple item lookup. We can review the buyer’s requested specification, quantity, packaging, destination, and documentation needs before preparing a quotation. Where a project has special requirements, buyers should describe them directly so that we can confirm feasibility instead of making assumptions.
4-Pyrazoleboronic acid pinacol ester CAS 269410-08-4 is a pyrazole-containing boronic ester relevant to Suzuki coupling and synthetic intermediate development. Its key procurement identifiers include the CAS number 269410-08-4, formula C9H15BN2O2, and approximate molecular weight of 194.04 g/mol. The correct purchasing decision depends on identity confirmation, batch documentation, specification control, handling information, quantity, lead time, and supplier responsiveness.
As the next step, send Maison Chemical your target quantity, required purity or specification, packaging preference, destination, and requested documents. We can then review the inquiry and provide a product-focused B2B quotation based on the actual project requirements. This approach gives procurement and technical teams a clearer basis for supplier comparison and Suzuki coupling planning.
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